作者
Sandra K Loo, Elaine Specter, Andrew Smolen, Christian Hopfer, Peter D Teale, Martin L Reite
发表日期
2003/8/1
期刊
Journal of the American Academy of Child & Adolescent Psychiatry
卷号
42
期号
8
页码范围
986-993
出版商
Elsevier
简介
OBJECTIVE
This paper examines whether dopamine transporter gene (DAT1) allele status mediates medication-related change in cognitive and neurophysiological measures among children with attention-deficiency/hyperactivity disorder (ADHD).
METHOD
A single 10-mg dose of methylphenidate was given in a double-blind, placebo-controlled fashion to children with ADHD who were seen for cognitive testing and EEG recording. Buccal samples were obtained and genotyped for the DAT1 polymorphism.
RESULTS
DAT1 allele status was associated with performance on a sustained attention task and medication-related EEG changes. Compared with those with one or more copies of the DAT1 9-repeat allele (9R), children with two copies of the 10-repeat allele (10R) exhibited poorer performance on the vigilance task. In addition, children with 10R exhibited medication-related EEG changes of increased central …
引用总数
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SK Loo, E Specter, A Smolen, C Hopfer, PD Teale… - Journal of the American Academy of Child & …, 2003