作者
Karen van Eunen, Pieter Dool, AB Canelas, J Kiewiet, J Bouwman, WM Van Gulik, HV Westerhoff, BM Bakker
发表日期
2010/3/1
期刊
IET systems biology
卷号
4
期号
2
页码范围
157-168
出版商
IET Digital Library
简介
In this study, the authors investigated how the glycolytic flux was regulated in time upon nitrogen starvation of cells with different growth histories. We have compared cells grown in glucose-limited chemostat cultures under respiratory conditions (low dilution rate of 0.1/h) to cells grown under respirofermentative conditions (high dilution rate of 0.35/h). The fermentative capacity was lower in cells grown under respiratory conditions than in cells grown under respirofermentative conditions, yet more resilient to prolonged nitrogen starvation. The time profiles revealed that the fermentative capacity even increased in cells grown under respiratory conditions during the first hours of nitrogen starvation. In cells grown under respirofermentative conditions the fermentative capacity decreased from the onset of nitrogen starvation. We have applied time-dependent Regulation Analysis to follow the fermentative capacity during …
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K van Eunen, P Dool, AB Canelas, J Kiewiet… - IET systems biology, 2010