作者
C Bourne, Ö Aydemir, V Balanzá‐Martínez, E Bora, S Brissos, JTO Cavanagh, L Clark, Z Cubukcuoglu, V Videira Dias, S Dittmann, IN Ferrier, DE Fleck, S Frangou, P Gallagher, L Jones, Tuula Kieseppä, A Martínez‐Aran, I Melle, PB Moore, Maria Mur, A Pfennig, A Raust, VESİLE Senturk, C Simonsen, DJ Smith, DS Bio, MG Soeiro‐de‐Souza, SDR Stoddart, K Sundet, A Szöke, JM Thompson, C Torrent, T Zalla, Nicholas Craddock, OA Andreassen, M Leboyer, E Vieta, M Bauer, PD Worhunsky, C Tzagarakis, RD Rogers, JR Geddes, GM Goodwin
发表日期
2013/9
来源
Acta Psychiatrica Scandinavica
卷号
128
期号
3
页码范围
149-162
简介
Objective
An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta‐analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view.
Method
Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task.
Results
Impairments were found for all 11 test‐measures in the bipolar group after controlling for age, IQ and gender (Ps ≤ 0.001, E.S. = 0.26–0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test‐measures were …
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C Bourne, Ö Aydemir, V Balanzá‐Martínez, E Bora… - Acta Psychiatrica Scandinavica, 2013