作者
Kyriaki Michailidou, Jonathan Beesley, Sara Lindstrom, Sander Canisius, Joe Dennis, Michael J Lush, Mel J Maranian, Manjeet K Bolla, Qin Wang, Mitul Shah, Barbara J Perkins, Kamila Czene, Mikael Eriksson, Hatef Darabi, Judith S Brand, Stig E Bojesen, Børge G Nordestgaard, Henrik Flyger, Sune F Nielsen, Nazneen Rahman, Clare Turnbull, BOCS, Olivia Fletcher, Julian Peto, Lorna Gibson, Isabel dos-Santos-Silva, Jenny Chang-Claude, Dieter Flesch-Janys, Anja Rudolph, Ursula Eilber, Sabine Behrens, Heli Nevanlinna, Taru A Muranen, Kristiina Aittomäki, Carl Blomqvist, Sofia Khan, Kirsimari Aaltonen, Habibul Ahsan, Muhammad G Kibriya, Alice S Whittemore, Esther M John, Kathleen E Malone, Marilie D Gammon, Regina M Santella, Giske Ursin, Enes Makalic, Daniel F Schmidt, Graham Casey, David J Hunter, Susan M Gapstur, Mia M Gaudet, W Ryan Diver, Christopher A Haiman, Fredrick Schumacher, Brian E Henderson, Loic Le Marchand, Christine D Berg, Stephen J Chanock, Jonine Figueroa, Robert N Hoover, Diether Lambrechts, Patrick Neven, Hans Wildiers, Erik van Limbergen, Marjanka K Schmidt, Annegien Broeks, Senno Verhoef, Sten Cornelissen, Fergus J Couch, Janet E Olson, Emily Hallberg, Celine Vachon, Quinten Waisfisz, Hanne Meijers-Heijboer, Muriel A Adank, Rob B van der Luijt, Jingmei Li, Jianjun Liu, Keith Humphreys, Daehee Kang, Ji-Yeob Choi, Sue K Park, Keun-Young Yoo, Keitaro Matsuo, Hidemi Ito, Hiroji Iwata, Kazuo Tajima, Pascal Guénel, Thérèse Truong, Claire Mulot, Marie Sanchez, Barbara Burwinkel, Frederik Marme, Harald Surowy, Christof Sohn, Anna H Wu, Chiu-chen Tseng, David Van Den Berg, Daniel O Stram, Anna González-Neira, Javier Benitez, M Pilar Zamora, Jose Ignacio Arias Perez, Xiao-Ou Shu, Wei Lu, Yu-Tang Gao, Hui Cai, Angela Cox, Simon S Cross, Malcolm WR Reed, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Elinor J Sawyer, Ian Tomlinson, Michael J Kerin, Nicola Miller, kConFab Investigators, AOCS Group, Annika Lindblom, Sara Margolin, Soo Hwang Teo, Cheng Har Yip, Nur Aishah Mohd Taib, Gie-Hooi Tan, Maartje J Hooning, Antoinette Hollestelle, John WM Martens, J Margriet Collée, William Blot, Lisa B Signorello, Qiuyin Cai, John L Hopper, Melissa C Southey, Helen Tsimiklis, Carmel Apicella, Chen-Yang Shen, Chia-Ni Hsiung, Pei-Ei Wu, Ming-Feng Hou, Vessela N Kristensen, Silje Nord, Grethe I Grenaker Alnaes, NBCS, Graham G Giles, Roger L Milne, Catriona McLean, Federico Canzian, Dimitrios Trichopoulos
发表日期
2015/4
期刊
Nature genetics
卷号
47
期号
4
页码范围
373-380
出版商
Nature Publishing Group US
简介
Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10−8. Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions …
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K Michailidou, J Beesley, S Lindstrom, S Canisius… - Nature genetics, 2015