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Patients lacking stable housing face significant medical morbidity, including increased rates of skin and soft tissue infections (SSTIs). While outbreaks of invasive group A streptococcal (GAS) disease, such as sepsis and pneumonia, have been reported among persons experiencing homelessness, only a single small study has examined housing status as a risk factor for non-invasive GAS infections, such as SSTIs. To determine if housing status is an independent risk factor for GAS SSTIs. We performed a retrospective cross-sectional study of hospitalized adult patients receiving dermatology consult services at UCSF Moffitt-Long Hospital or Zuckerberg San Francisco General Hospital between March 2018 and March 2020 who were diagnosed with an SSTI and had skin microbiology data available. We developed logistic regression models to examine whether housing status was independently associated with GAS SSTI in unadjusted analysis and after adjusting for age, gender, alcohol use and injection drug use. Our analysis captured 209 patients, with 150 having stable housing and 59 lacking stable housing. GAS was cultured from skin in 42% of patients lacking stable housing and 17% of patients with stable housing. In simple logistic regression, patients lacking stable housing had 3.51 times the odds (95% CI 1.80 to 6.84; p< 0.001) of GAS positivity relative to patients with stable housing. In multiple logistic regression adjusting for potential confounders, patients had 3.95 times the odds (95% CI 1.87 to 8.38; p< 0.001) of GAS positivity if they lacked stable housing. Our results suggest that …