作者
Abadi Kahsu Gebre, Marc Sim, Jack Dalla Via, Cassandra Smith, Alexander J Rodriguez, Jonathan M Hodgson, Catherine P Bondonno, Wai Lim, Elizabeth Byrnes, Peter R Thompson, Richard L Prince, Joshua R Lewis
发表日期
2024/1/1
期刊
Heart
卷号
110
期号
2
页码范围
108-114
出版商
BMJ Publishing Group Ltd and British Cardiovascular Society
简介
Objective
To examine the association between high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, muscle function decline and 14.5-year fall-related hospitalisation risk in women aged over 70 years.
Methods
1179 ambulatory community-dwelling women aged over 70 years with subclinical levels of hs-cTnI (ie, <15.6 ng/L), who were followed up for 14.5 years, were included. Samples for hs-cTnI were obtained in 1998. Fall-related hospitalisations were retrieved from linked health records. Muscle function measures, including handgrip strength and the Timed-Up-and-Go (TUG) test, were assessed in 1998 and 2003.
Results
Mean±SD age was 75.2±2.7 years. Over 14.5 years of follow-up, 40.4% (476 of 1179) experienced fall-related hospitalisation. Participants were categorised into four approximate hs-cTnI quartiles: quartile 1 (<3.6 ng/L), quartile 2 (3.6–4.4 ng/L), quartile 3 (4.5–5.8 ng …
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AK Gebre, M Sim, J Dalla Via, C Smith, AJ Rodriguez… - Heart, 2024