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To evaluate the effect of intraocular pressure (IOP) reduction on long-termprogression or stability in patients with exfoliation glaucoma.

Multicenter (Greece, Spain, Russia, and Hungary), retrospective analysis.

Medical record analysis of 167 patients with at least 5 years of follow-up,who were stable (n = 85) or whose condition had progressed (n = 82) afterthe beginning of the follow-up period.

The mean ± SD IOP was 18.1 ± 2.6 mm Hg in the stable groupand 20.1 ± 4.3 mm Hg in the progressed group (P<.001).The mean ± SD follow-up time was 6.1 ± 2.3 years for the stablegroup and 3.4 ± 1.7 years for the progressed group. The mean SD foreach patient's average IOP was 2.9 mm Hg for the stable group and 4.6 mm Hgfor the progressed group (P<.001). Twenty-eightpercent of patients who had a mean IOP of 17 mm Hg or lower, 43% of thosewith an IOP of 18 to 19 mm Hg, and 70 …