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Hydrogen sulfide (H₂S) has been recognized to influence a wide range of physiological and pathological processes. Its underlying molecular events, however, are still poorly understood. An activatable H₂S probe for photoacoustic (PA) imaging is desirable to further explore the role of H₂S in vivo. Nevertheless, only a few activatable PA probes for H₂S detection have been reported. In particular, examples of dual-modal H₂S probes with the combined advantages of fluorescence (high sensitivity and resolution) and PA imaging (deep penetration) are very rare. Herein the controllable cleavage of the C–N bond in nitrobenzoxadiazole (NBD) amine derivatives by H₂S is presented for the first time. The cleavage reactivity was found to be accelerated by the introduction of an electron-withdrawing group. Through this strategy, a series of fluorescent and PA dual-modal probes (1–3) were developed for H₂S detection …