查看文章

Zataria multiflora is an aromatic plant that is used in flavouring and preserving foods and also used as an antispasmodic, anaesthetic and antinociceptive agent. In this study, the effects of Z. multiflora essential oil on nitric oxide (NO) and hydrogen peroxide (H₂O₂) production in lipopolysaccharide (LPS)-stimulated macrophages was investigated.

Z. multiflora essential oil was extracted by water-distillation, analysed by GC-MS and then the effect of the essential oil on NO and H₂O₂ production was investigated.

Carvacrol (52%), thymol (16%) and p-cymene (10%) were the main components of the oil. The IC50 (concentration providing 50% inhibition) for reactive oxygen scavenging was estimated to be 5.7, 3 and 4.2 µg/ml for the essential oil, thymol and carvacrol, respectively, while the corresponding IC50 …