作者
Gian Paolo Fadini, Marta Miorin, Monica Facco, Sondra Bonamico, Ilenia Baesso, Franco Grego, Mirko Menegolo, Saula Vigili de Kreutzenberg, Antonio Tiengo, Carlo Agostini, Angelo Avogaro
发表日期
2005/5/3
期刊
Journal of the American College of Cardiology
卷号
45
期号
9
页码范围
1449-1457
出版商
American College of Cardiology Foundation
简介
Objectives
We sought to establish whether a reduction in endothelial progenitor cells (EPCs) has a putative role in peripheral vascular disease (PVD) of type 2 diabetic patients.
Background
Peripheral vascular disease is a common and severe complication of diabetes mellitus. Impaired collateralization of diabetic vasculopathy has been extensively shown, but causes leading to its pathogenesis are not fully understood. Recently, EPCs have been found to contribute to vascular repair and angiogenesis. Diabetes has been associated with low levels of circulating EPCs, but no data are available in the literature on the relationship between EPCs and PVD in diabetes.
Methods
Flow cytometric analysis was used to quantify circulating progenitor cells (CPCs, CD34+) and EPCs (CD34+KDR+) in 51 patients and 17 control subjects.
Results
The CPCs and EPCs from diabetic patients were reduced by 33% and 40 …
引用总数
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GP Fadini, M Miorin, M Facco, S Bonamico, I Baesso… - Journal of the American College of Cardiology, 2005
