作者
Minetta C Liu, GR Oxnard, EA Klein, CSMCC Swanton, MV Seiden, Minetta C Liu, Geoffrey R Oxnard, Eric A Klein, David Smith, Donald Richards, Timothy J Yeatman, Allen L Cohn, Rosanna Lapham, Jessica Clement, Alexander S Parker, Mohan K Tummala, Kristi McIntyre, Mikkael A Sekeres, Alan H Bryce, Robert Siegel, Xuezhong Wang, David P Cosgrove, Nadeem R Abu-Rustum, Jonathan Trent, David D Thiel, Carlos Becerra, Manish Agrawal, Lawrence E Garbo, Jeffrey K Giguere, Ross M Michels, Ronald P Harris, Stephen L Richey, Timothy A McCarthy, David M Waterhouse, Fergus J Couch, Sharon T Wilks, Amy K Krie, Rama Balaraman, Alvaro Restrepo, Michael W Meshad, Kimberly Rieger-Christ, Travis Sullivan, Christine M Lee, Daniel R Greenwald, William Oh, Che-Kai Tsao, Neil Fleshner, Hagen F Kennecke, Maged F Khalil, David R Spigel, Atisha P Manhas, Brian K Ulrich, Philip A Kovoor, Christopher Stokoe, Jay G Courtright, Habte A Yimer, Timothy G Larson, Charles Swanton, Michael V Seiden, Steven R Cummings, Inc GRAIL, Farnaz Absalan, Gregory Alexander, Brian Allen, Hamed Amini, Alexander M Aravanis, Siddhartha Bagaria, Leila Bazargan, John F Beausang, Jennifer Berman, Craig Betts, Alexander Blocker, Joerg Bredno, Robert Calef, Gordon Cann, Jeremy Carter, Christopher Chang, Hemanshi Chawla, Xiaoji Chen, Tom C Chien, Daniel Civello, Konstantin Davydov, Vasiliki Demas, Mohini Desai, Zhao Dong, Saniya Fayzullina, Alexander P Fields, Darya Filippova, Peter Freese, Eric T Fung, Sante Gnerre, Samuel Gross, Meredith Halks-Miller, Megan P Hall, Anne-Renee Hartman, Chenlu Hou, Earl Hubbell, Nathan Hunkapiller, Karthik Jagadeesh, Arash Jamshidi, Roger Jiang, Byoungsok Jung, TaeHyung Kim, Richard D Klausner, Kathryn N Kurtzman, Mark Lee, Wendy Lin, Jafi Lipson, Hai Liu, Qinwen Liu, Margarita Lopatin, Tara Maddala, M Cyrus Maher, Collin Melton, Andrea Mich, Shivani Nautiyal, Jonathan Newman, Joshua Newman, Virgil Nicula, Cosmos Nicolaou, Ongjen Nikolic, Wenying Pan, Shilpen Patel, Sarah A Prins, Richard Rava, Neda Ronaghi, Onur Sakarya, Ravi Vijaya Satya, Jan Schellenberger, Eric Scott, Amy J Sehnert, Rita Shaknovich, Avinash Shanmugam, KC Shashidhar, Ling Shen, Archana Shenoy, Seyedmehdi Shojaee, Pranav Singh, Kristan K Steffen, Susan Tang, Jonathan M Toung, Anton Valouev, Oliver Venn, Richard T Williams, Tony Wu, Hui H Xu, Christopher Yakym, Xiao Yang, Jessica Yecies, Alexander S Yip
发表日期
2020/6/1
期刊
Annals of Oncology
卷号
31
期号
6
页码范围
745-759
出版商
Elsevier
简介
Background
Early cancer detection could identify tumors at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study (from NCT02889978 and NCT03085888) assessed the performance of targeted methylation analysis of circulating cell-free DNA (cfDNA) to detect and localize multiple cancer types across all stages at high specificity.
Participants and methods
The 6689 participants [2482 cancer (>50 cancer types), 4207 non-cancer] were divided into training and validation sets. Plasma cfDNA underwent bisulfite sequencing targeting a panel of >100 000 informative methylation regions. A classifier was developed and validated for cancer detection and tissue of origin (TOO) localization.
Results
Performance was consistent in training and validation sets. In validation, specificity was 99.3% [95% confidence interval (CI): 98.3% to 99.8%; 0.7% false-positive rate (FPR …
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MC Liu, GR Oxnard, EA Klein, C Swanton, MV Seiden… - Annals of Oncology, 2020