作者
Herbert A Mbunkah, Silvia Bertagnolio, Raph L Hamers, Gillian Hunt, Seth Inzaule, Tobias F Rinke De Wit, Roger Paredes, Neil T Parkin, Michael R Jordan, Karin J Metzner, WHO HIVResNet Working Group
发表日期
2020/4/27
来源
The Journal of infectious diseases
卷号
221
期号
10
页码范围
1584-1597
出版商
Oxford University Press
简介
Background
The presence of high-abundance drug-resistant HIV-1 jeopardizes success of antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low-abundance drug-resistant HIV-1 variants (LA-DRVs) at levels <15%–25% of the virus population in antiretroviral (ARV) drug-naive individuals remains controversial.
Methods
We systematically reviewed 103 studies assessing prevalence, detection methods, technical and clinical detection cutoffs, and clinical significance of LA-DRVs in antiretroviral drug-naive adults.
Results
In total, 14 919 ARV drug-naive individuals were included. Prevalence of LA-DRVs (ie, proportion of individuals harboring LA-DRVs) was 0%–100%. Technical detection cutoffs showed a 4 log range (0.001%–10%); 42/103 (40.8%) studies investigating the impact of LA-DRVs on ART; 25 studies included only …
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HA Mbunkah, S Bertagnolio, RL Hamers, G Hunt… - The Journal of infectious diseases, 2020