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The natural tendency of polymicrobial infections and co-habitation of bacteria and Candida are currently well-recognized and reported as highly fatal. This kind of interaction is usually associated with drug tolerance, infection relapse, persistence and high mortality. The interest in natural products has emerged and their potential applicability as therapeutic strategies is being constantly explored.

The main goal of this work is to evaluate the effect of the hydroethanolic extract of Glycyrrhiza glabra, and Manuka honey, in Staphylococcus aureus and Candida tropicalis planktonic cells and single and mixed biofilms.

The effect of both the G. glabra extract and the honey was evaluated by determination of the minimum inhibitory/bactericidal/fungicidal concentrations and by determination of their antibiofilm activity (alone and in combination) on single and mixed-species biofilms. In addition …