作者
Tory Prestera, Paul Talalay, Jawed Alam, Young I Ahn, Patty J Lee, Augustine MK Choi
发表日期
1995/11
期刊
Molecular Medicine
卷号
1
页码范围
827-837
出版商
BioMed Central
简介
Background
Heme oxygenase (HO; EC 1.14.99.3) catalyzes the conversion of heme to biliverdin, which is reduced enzymatically to bilirubin. Since bilirubin is a potent antioxidant and heme a pro-oxidant, HO may protect cells against oxidative damage. HO-1 is highly inducible by diverse chemical agents, resembling those evoking induction of phase 2 enzymes (i.e., Michael reaction acceptors, heavy metals, trivalent arsenicals, and sulfhydryl reagents). Phase 2 enzymes (glutathione transferases; NAD(P)H:quinone reductase; glucuronosyltransferases) are regulated by antioxidant-responsive elements (ARE), and their induction protects against chemical carcinogenesis. Is HO-1 regulated by chemical agents and enhancer elements similar to those controlling phase 2 enzymes?
Materials and Methods
Induction of HO-1 by phorbol ester and heavy metals …
引用总数
学术搜索中的文章
T Prestera, P Talalay, J Alam, YI Ahn, PJ Lee… - Molecular Medicine, 1995