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There is rapidly developing interest into the role of several anti‐inflammatory agents to resolve inflammation in periodontal disease. A bioactive polyunsaturated fatty acid, 10‐oxo‐trans‐11‐octadecenoic acid (KetoC), is known to have various beneficial physiological effects; however, the effect of KetoC on inflammation remains unclear. Here, we investigated the effect of KetoC on RAW 264.7 cells stimulated with Porphyromonas gingivalis lipopolysaccharide, and explored the intracellular mechanism responsible for its anti‐inflammatory effects.

RAW 264.7 cells were pre‐treated with or without KetoC, and then stimulated with or without P. gingivalis lipopolysaccharide. Levels of tumor necrosis factor α (TNFα), interleukin (IL)‐6 and IL‐1β were determined by real‐time polymerase chain reaction and enzyme‐linked immunosorbent assay. Specific antagonists for G protein‐coupled receptor …