作者
Dominique J Pepper, Suzaan Marais, Gary Maartens, Kevin Rebe, Chelsea Morroni, Molebogeng X Rangaka, Tolu Oni, Robert J Wilkinson, Graeme Meintjes
发表日期
2009/6/1
期刊
Clinical Infectious Diseases
卷号
48
期号
11
页码范围
e96-e107
出版商
The University of Chicago Press
简介
Background. Paradoxical neurologic tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a potentially life-threatening condition that occurs within 3 months after starting combination antiretroviral therapy (ART). The reports in the published literature are anecdotal, and the prevalence and outcomes of neurologic TB-IRIS are unknown.
Methods. We prospectively assessed patients with suspected TB-IRIS from June 2005 through October 2007 at our hospital in Cape Town, South Africa. We defined paradoxical TB-IRIS and paradoxical neurologic TB-IRIS with use of consensus clinical case definitions. We collected data on tuberculosis diagnosis, ART, details of TB-IRIS diagnosis, other opportunistic infections, corticosteroid use, and outcome.
Results. We reviewed 279 patients with suspected TB-IRIS, 54 (19%) of …
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DJ Pepper, S Marais, G Maartens, K Rebe, C Morroni… - Clinical Infectious Diseases, 2009