作者
Graeme Meintjes, Keira H Skolimowska, Katalin A Wilkinson, Kerryn Matthews, Rebecca Tadokera, Anali Conesa-Botella, Ronnett Seldon, Molebogeng X Rangaka, Kevin Rebe, Dominique J Pepper, Chelsea Morroni, Robert Colebunders, Gary Maartens, Robert J Wilkinson
发表日期
2012/8/15
期刊
American journal of respiratory and critical care medicine
卷号
186
期号
4
页码范围
369-377
出版商
American Thoracic Society
简介
Rationale: HIV–tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an immunopathological reaction to mycobacterial antigens induced by antiretroviral therapy. Prednisone reduces morbidity in TB-IRIS, but the mechanisms are unclear.
Objectives: To determine the effect of prednisone on the inflammatory response in TB-IRIS (antigen-specific effector T cells, cytokines, and chemokines).
Methods: Blood was taken from participants in a randomized placebo-controlled trial of prednisone for TB-IRIS, at 0, 2, and 4 weeks. Participants received prednisone at a dosage of 1.5 mg/kg/day for 2 weeks followed by 0.75 mg/kg/day for 2 weeks, or placebo at identical dosages.
Measurements and Main Results: Analyses included IFN-γ enzyme-linked immunospot (ELISPOT), reverse transcription-polymerase chain reaction on peripheral blood mononuclear cells after restimulation with heat-killed …
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G Meintjes, KH Skolimowska, KA Wilkinson… - American journal of respiratory and critical care …, 2012