作者
Mika Kivimäki, Ritva Luukkonen, G David Batty, Jane E Ferrie, Jaana Pentti, Solja T Nyberg, Martin J Shipley, Lars Alfredsson, Eleonor I Fransson, Marcel Goldberg, Anders Knutsson, Markku Koskenvuo, Eeva Kuosma, Maria Nordin, Sakari B Suominen, Töres Theorell, Eero Vuoksimaa, Peter Westerholm, Hugo Westerlund, Marie Zins, Miia Kivipelto, Jussi Vahtera, Jaakko Kaprio, Archana Singh-Manoux, Markus Jokela
发表日期
2018/5/1
期刊
Alzheimer's & Dementia
卷号
14
期号
5
页码范围
601-609
出版商
No longer published by Elsevier
简介
Introduction
Higher midlife body mass index (BMI) is suggested to increase the risk of dementia, but weight loss during the preclinical dementia phase may mask such effects.
Methods
We examined this hypothesis in 1,349,857 dementia-free participants from 39 cohort studies. BMI was assessed at baseline. Dementia was ascertained at follow-up using linkage to electronic health records (N = 6894). We assumed BMI is little affected by preclinical dementia when assessed decades before dementia onset and much affected when assessed nearer diagnosis.
Results
Hazard ratios per 5-kg/m2 increase in BMI for dementia were 0.71 (95% confidence interval = 0.66–0.77), 0.94 (0.89–0.99), and 1.16 (1.05–1.27) when BMI was assessed 10 years, 10-20 years, and >20 years before dementia diagnosis.
Conclusions
The association between BMI and dementia is likely to be attributable to two different processes: a harmful …
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