作者
Kari R Risnes, Lars J Vatten, Jennifer L Baker, Karen Jameson, Ulla Sovio, Eero Kajantie, Merete Osler, Ruth Morley, Markus Jokela, Rebecca C Painter, Valter Sundh, Geir W Jacobsen, Johan G Eriksson, Thorkild IA Sørensen, Michael B Bracken
发表日期
2011/6/1
来源
International journal of epidemiology
卷号
40
期号
3
页码范围
647-661
出版商
Oxford University Press
简介
Background Small birth size may be associated with increased risk of cardiovascular diseases (CVD), whereas large birth size may predict increased risk of obesity and some cancers. The net effect of birth size on long-term mortality has only been assessed in individual studies, with conflicting results.
Methods The Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines for conducting and reporting meta-analysis of observational studies were followed. We retrieved 22 studies that assessed the association between birthweight and adult mortality from all causes, CVD or cancer. The studies were systematically reviewed and those reporting hazard ratios (HRs) and 95% confidence intervals (95% CIs) per kilogram (kg) increase in birthweight were included in generic inverse variance meta-analyses.
Results For all-cause mortality, 36 834 deaths were included …
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