作者
Adriana M Hung, Victoria A Assimon, Hua-Chang Chen, Zhihong Yu, Caitlyn Vlasschaert, Jefferson L Triozzi, Helen Chan, Lee Wheless, Otis Wilson, Shailja C Shah, Taralynn Mack, Trevor Thompson, Michael E Matheny, Saranya Chandrasekar, Sahar V Mozaffari, Cecilia P Chung, Philip Tsao, Katalin Susztak, Edward D Siew, Karol Estrada, J Michael Gaziano, Robert R Graham, Ran Tao, Maarten Hoek, Cassianne Robinson-Cohen, Eric M Green, Alexander G Bick
发表日期
2023/11/1
期刊
Journal of the American Society of Nephrology
卷号
34
期号
11
页码范围
1889-1899
出版商
LWW
简介
Background
African Americans are at increased risk for nondiabetic CKD in part due to HR variants in the APOL1 gene.
Methods
We tested whether a different APOL1 variant, p. N264K, modified the association between APOL1 HR genotypes (two copies of G1/G2) and CKD in a cross-sectional analysis of 121,492 participants of African ancestry from the MVP. We replicated our findings in the Vanderbilt University Biobank (n= 14,386) and National Institutes of Health All of Us (n= 14,704). Primary outcome was CKD and secondary outcome was ESKD among nondiabetic patients. Primary analysis compared APOL1 HR genotypes with and without p. N264K. Secondary analyses included APOL1 low-risk genotypes and tested for interaction. In MVP, we performed sequential logistic regression models adjusting for demographics, comorbidities, medications, and ten principal components of ancestry. Functional genomic …
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AM Hung, VA Assimon, HC Chen, Z Yu, C Vlasschaert… - Journal of the American Society of Nephrology, 2023