作者
Caitlyn Vlasschaert, Amy JM McNaughton, Michael Chong, Elina K Cook, Wilma Hopman, Bryan Kestenbaum, Cassianne Robinson-Cohen, Jocelyn Garland, Sarah M Moran, Guillaume Paré, Catherine M Clase, Mila Tang, Adeera Levin, Rachel Holden, Michael J Rauh, Matthew B Lanktree
发表日期
2022/5/1
期刊
Journal of the American Society of Nephrology
卷号
33
期号
5
页码范围
985-995
出版商
LWW
简介
Background
Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells. This condition is common in aging populations and associated with cardiovascular morbidity and overall mortality, but its role in CKD is unknown.
Methods
We performed targeted sequencing to detect CHIP mutations in two independent cohorts of 87 and 85 adults with an eGFR< 60 ml/min per 1.73 m 2. We also assessed kidney function, hematologic, and mineral bone disease parameters cross-sectionally at baseline, and collected creatinine measurements over the following 5-year period.
Results
At baseline, CHIP was detected in 18 of 87 (21%) and 25 of 85 (29%) cohort participants. Participants with CHIP were at higher risk of kidney failure, as predicted by the Kidney Failure Risk Equation (KFRE), compared with those without CHIP …
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C Vlasschaert, AJM McNaughton, M Chong, EK Cook… - Journal of the American Society of Nephrology, 2022