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The aim of this study was to investigate the efficacy of a polymeric delivery system impregnated with chlorhexidine or fluconazole against Candida species.

Self-cure poly-ethyl methacrylate and tetrahydro-furfuryl methacrylate (PEM/THFM) discs impregnated with pure fluconazole substance (FLUp), fluconazole powder from capsules (FLUc) or chlorhexidine powder (CHX) were incubated in water for up to 28 days at 37°C. The water was replaced at 24h and 3, 7, 14, 21, 28 days. The amount of released drugs and antifungal activity of the leachates was measured by bioassay. The minimal inhibitory concentration (MIC) of each drug for 46 Candida isolates was determined and compared to the released concentrations.

A total of 53.0% of CHX, 38.5% of FLUc and 13.2% of FLUp impregnated into the discs was leached during the 28-day incubation. Of the total amount leached, 71.8 …