作者
Rosanna Coppo, Licia Peruzzi, Elisa Loiacono, Massimilano Bergallo, Alexandra Krutova, Maria Luisa Russo, Enrico Cocchi, Alessandro Amore, Sigrid Lundberg, Dita Maixnerova, Vladimir Tesar, Agnieszka Perkowska-Ptasińska, Magdalena Durlik, Dimitris Goumenos, Miltiadis Gerolymos, Kresimir Galesic, Luka Toric, Aikaterini Papagianni, Maria Stangou, Malgorzata Mizerska-Wasia Membek, Loreto Gesualdo, Eustacchio Montemurno, Luisa Benozzi, Stefano Cusinato, Tomasz Hryszko, Marian Klinger, Dorota Kamińska, Magdalena Krajewska, VALIGA Study Group of the ERA-EDTA Immunonephrology Working Group
发表日期
2019/4/1
期刊
Nephrology Dialysis Transplantation
卷号
34
期号
4
页码范围
587-596
出版商
Oxford University Press
简介
Background
Complement is thought to play a role in immunoglobulin A nephropathy (IgAN), though the activating mechanisms are unknown. This study focused on the gene expression of CD46 and CD55, two key molecules for regulating C3 convertase activity of lectin and alternative complement pathways at a cellular level.
Methods
The transcriptional expression in peripheral white blood cells (WBCs) of CD46 and CD55 was investigated in 157 patients enrolled by the Validation of the Oxford Classification of IgAN group, looking for correlations with clinical and pathology features and estimated glomerular filtration rate (eGFR) modifications from renal biopsy to sampling. Patients had a previous median follow-up of 6.4 (interquartile range 2.8–10.7) years and were divided into progressors and non-progressors according to the median value of their velocity of loss of renal …
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R Coppo, L Peruzzi, E Loiacono, M Bergallo, A Krutova… - Nephrology Dialysis Transplantation, 2019