作者
Jérôme Mairesse, Jean Lesage, Christophe Breton, Bernadette Bréant, Tom Hahn, Muriel Darnaudéry, Suzanne L Dickson, Jonathan Seckl, Bertrand Blondeau, Didier Vieau, Stefania Maccari, Odile Viltart
发表日期
2007/6
期刊
American Journal of Physiology-Endocrinology and Metabolism
卷号
292
期号
6
页码范围
E1526-E1533
出版商
American Physiological Society
简介
Prenatal stress (PS) can cause early and long-term developmental effects resulting in part from altered maternal and/or fetal glucocorticoid exposure. The aim of the present study was to assess the impact of chronic restraint stress during late gestation on feto-placental unit physiology and function in embryonic (E) day 21 male rat fetuses. Chronic stress decreased body weight gain and food intake of the dams and increased their adrenal weight. In the placenta of PS rats, the expression of glucose transporter type 1 (GLUT1) was decreased, whereas GLUT3 and GLUT4 were slightly increased. Moreover, placental expression and activity of the glucocorticoid “barrier” enzyme 11β-hydroxysteroid dehydrogenase type 2 was strongly reduced. At E21, PS fetuses exhibited decreased body, adrenal pancreas, and testis weights. These alterations were associated with reduced pancreatic β-cell mass, plasma levels of …
引用总数
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J Mairesse, J Lesage, C Breton, B Bréant, T Hahn… - American Journal of Physiology-Endocrinology and …, 2007