作者
Ilse Ceelie, Saskia N De Wildt, Monique Van Dijk, Margreeth MJ van den Berg, Gerbrich E Van Den Bosch, Hugo J Duivenvoorden, Tom G De Leeuw, Ron Mathôt, Catherijne AJ Knibbe, Dick Tibboel
发表日期
2013/1/9
期刊
Jama
卷号
309
期号
2
页码范围
149-154
出版商
American Medical Association
简介
Importance
Continuous morphine infusion as standard postoperative analgesic therapy in young infants is associated with unwanted adverse effects such as respiratory depression.
Objective
To determine whether intravenous paracetamol (acetaminophen) would significantly (>30%) reduce morphine requirements in neonates and infants after major surgery.
Design, Setting, and Patients
Single-center, randomized, double-blind study conducted in a level 3 pediatric intensive care unit in Rotterdam, the Netherlands. Patients were 71 neonates or infants younger than 1 year undergoing major thoracic (noncardiac) or abdominal surgery between March 2008 and July 2010, with follow-up of 48 hours.
Interventions
All patients received a loading dose of morphine 30 minutes before the end of surgery, followed by continuous morphine or intermittent intravenous paracetamol up to 48 hours postsurgery. Infants in both study …
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I Ceelie, SN De Wildt, M Van Dijk, MMJ van den Berg… - Jama, 2013