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Results

Measurement of cysC or iohexol-based mGFR failed in 6 patient; demographic data in these patients did not systematically differ from the analyzed cohort. At inclusion, median age was 2 (range 0–27) days for neonates (n= 42) and 6.0 (range 0.1–17.2) years for children (n= 57). Median cysC levels were 1.2 (IQR 1.1–1.4) mg/l for neonates, and 0.8 (IQR 0.6–1.2) mg/l for children. Neonates had a median mGFR of 29.2 (IQR 22.3–35.5) ml/min per 1.73 m 2, and children had a mediam mGFR of 82.2 (IQR 43.3–115.5) ml/min per 1.73 m 2. According to the Kidney Disease Improving Global Outcomes criteria, 26 patients were diagnosed with acute kidney injury (8 neonates, 18 children). In neonates, the relationship between cysC and mGFR was statistically significant, but poor (r=− 0.30 [95% confidence interval− 0.55 to 0.00], P= 0.050), whereas in children, this relationship was stronger (r=− 0.77 (95% CI− 0.86 …