作者
Gerdien Zeilmaker-Roest, Christine de Vries-Rink, Joost van Rosmalen, Monique van Dijk, Saskia N de Wildt, Catherijne AJ Knibbe, Erik Koomen, Nicolaas JG Jansen, Martin CJ Kneyber, Sofie Maebe, Greet Van den Berghe, Renata Haghedooren, Dirk Vlasselaers, Ad JJC Bogers, Dick Tibboel, Enno D Wildschut
发表日期
2024/4/30
期刊
Critical Care
卷号
28
期号
1
页码范围
143
出版商
BioMed Central
简介
Background
To determine whether intermittent intravenous (IV) paracetamol as primary analgesic would significantly reduce morphine consumption in children aged 0–3 years after cardiac surgery with cardiopulmonary bypass.
Methods
Multi-center, randomized, double-blinded, controlled trial in four level-3 Pediatric Intensive Care Units (PICU) in the Netherlands and Belgium. Inclusion period; March 2016–July 2020. Children aged 0–3 years, undergoing cardiac surgery with cardiopulmonary bypass were eligible. Patients were randomized to continuous morphine or intermittent IV paracetamol as primary analgesic after a loading dose of 100 mcg/kg morphine was administered at the end of surgery. Rescue morphine was given if numeric rating scale (NRS) pain scores exceeded predetermined cutoff values. Primary outcome was median weight-adjusted cumulative morphine dose in mcg/kg in the first 48 h …
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