作者
Marko Sever, Robert Klicek, Bozo Radic, Luka Brcic, Ivan Zoricic, Domagoj Drmic, Mihovil Ivica, Ivan Barisic, Spomenko Ilic, Lidija Berkopic, Alenka Boban Blagaic, Marijana Coric, Danijela Kolenc, Hrvoje Vrcic, Tomislav Anic, Sven Seiwerth, Predrag Sikiric
发表日期
2009/10
期刊
Digestive diseases and sciences
卷号
54
页码范围
2070-2083
出版商
Springer US
简介
The gastric pentadecapeptide BPC 157, which was shown to be safe as an antiulcer peptide in trials for inflammatory bowel disease (PL14736, Pliva), successfully healed intestinal anastomosis and fistula in rat. Therefore, we studied for 4 weeks rats with escalating short bowel syndrome and progressive weight loss after small bowel resection from fourth ileal artery cranially of ileocecal valve to 5 cm beneath pylorus. BPC 157 (10 μg/kg or 10 ng/kg) was given perorally, in drinking water (12 ml/rat/day) or intraperitoneally (once daily, first application 30 min following surgery, last 24 h before sacrifice). Postoperatively, features of increasingly exhausted presentation were: weight loss appearing immediately regardless of villus height, twofold increase in crypt depth and fourfold increase in muscle thickness within the first week, jejunal and ileal overdilation, and disturbed jejunum/ileum relation. In contrast …
引用总数
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学术搜索中的文章
M Sever, R Klicek, B Radic, L Brcic, I Zoricic, D Drmic… - Digestive diseases and sciences, 2009