作者
Jon Mork, A Kathrine Lie, Eystein Glattre, Sarah Clark, Göran Hallmans, Egil Jellum, Pentti Koskela, Bjørn Møller, Eero Pukkala, John T Schiller, Zhaohui Wang, Linda Youngman, Matti Lehtinen, Joakim Dillner
发表日期
2001/4/12
期刊
New England Journal of Medicine
卷号
344
期号
15
页码范围
1125-1131
出版商
Massachusetts Medical Society
简介
Background
Oncogenic human papillomaviruses (HPVs), especially HPV type 16 (HPV-16), cause anogenital epithelial cancers and are suspected of causing epithelial cancers of the head and neck.
Methods
To examine the relation between head and neck cancers and HPVs, we performed a nested case–control study within a joint Nordic cohort in which serum samples were collected from almost 900,000 subjects. Samples collected at enrollment from 292 persons in whom squamous-cell carcinoma of the head and neck developed, on average, 9.4 years after enrollment and from 1568 matched controls were analyzed for antibodies against HPV-16, HPV-18, HPV-33, and HPV-73 and for cotinine levels as a marker of smoking habits. Polymerase-chain-reaction (PCR) analyses for HPV DNA were performed in tumor tissue from 160 of the study patients with cancer.
Results
After adjustment for cotinine levels …
引用总数
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J Mork, AK Lie, E Glattre, S Clark, G Hallmans, E Jellum… - New England Journal of Medicine, 2001
