作者
Joseph F Cheer, Kate M Wassum, Leslie A Sombers, Michael LAV Heien, Jennifer L Ariansen, Brandon J Aragona, Paul EM Phillips, R Mark Wightman
发表日期
2007/1/24
期刊
Journal of Neuroscience
卷号
27
期号
4
页码范围
791-795
出版商
Society for Neuroscience
简介
Transient surges of dopamine in the nucleus accumbens are associated with drug seeking. Using a voltammetric sensor with high temporal and spatial resolution, we demonstrate differences in the temporal profile of dopamine concentration transients caused by acute doses of nicotine, ethanol, and cocaine in the nucleus accumbens shell of freely moving rats. Despite differential release dynamics, all drug effects are uniformly inhibited by administration of rimonabant, a cannabinoid receptor (CB1) antagonist, suggesting that an increase in endocannabinoid tone facilitates the effects of commonly abused drugs on subsecond dopamine release. These time-resolved chemical measurements provide unique insight into the neurobiological effectiveness of rimonabant in treating addictive disorders.
引用总数
学术搜索中的文章
JF Cheer, KM Wassum, LA Sombers, MLAV Heien… - Journal of Neuroscience, 2007