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It is now a well-documented fact that there is a distinct relation between fish nutrition and health status. Intensification of aquaculture practice to meet market demand causes stress and elevates the risk of the disease outbreak. Therefore, provisions of proper diets as well as appropriate feeding regimens are of high importance in intensive aquaculture. Considering the negative impacts raised by prophylactic and therapeutic use of antibiotic in aquaculture, administration of dietary immunostimulant has been suggested as an alternative to antimicrobial agents. In this sense, functional dietary supplements, including pre-, pro- and synbiotic received increasing attention as an environment-friendly strategy for improving fish health. During the past years, administration of prebiotics in the diet of different fish species revealed promising results in immune response. In the present review article, the topic of the administration …