作者
Anthony F Jorm, Peter Butterworth, Kaarin J Anstey, H Christensen, Simon Easteal, J Maller, KA Mather, RI Turakulov, Wei Wen, Perminder Sachdev
发表日期
2004/11
期刊
Psychological medicine
卷号
34
期号
8
页码范围
1495-1506
出版商
Cambridge University Press
简介
Background
Previous research has found that depression is a major cause of memory complaints. However, there is evidence that memory complaints also weakly predict cognitive decline and dementia. The present study examined a range of possible determinants of memory complaints, covering psychiatric and personality factors, medical history, cognitive test performance, and biological risk factors for dementia (APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities).
Method
A community survey was carried out with 2546 persons aged 60–64 years living in Canberra and Queanbeyan, Australia. Participants were asked about memory problems which interfered with daily life and whether medical help had been sought. A randomly selected subsample of 476 persons was given a brain MRI scan.
Results
Participants with memory complaints were found to have poorer memory …
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