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Background Extremely low frequency (ELF) electromagnetic fields (EMF) are known to produce a variety of biological effects. Clinical studies are ongoing using EMF in healing of bone fractures and skin wounds. However, little is known about the mechanisms of action of ELF‐EMF. Several studies have demonstrated that expression and regulation of nitric oxide synthase (NOS) and cyclooxygenase‐2 (COX‐2) are vital for wound healing; however, no reports have demonstrated a direct action of ELF‐EMF in the modulation of these inflammatory molecules in human keratinocytes.

Objectives The present study analysed the effect of ELF‐EMF on the human keratinocyte cell line HaCaT in order to assess the mechanisms of action of ELF‐EMF and to provide further support for their therapeutic use in wound healing.

Methods Exposed HaCaT cells were compared with unexposed …