作者
Aharon Razin, Arthur D Riggs
发表日期
1980/11/7
来源
Science
卷号
210
期号
4470
页码范围
604-610
出版商
American Association for the Advancement of Science
简介
In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of many cytosine residues to 5-methylcytosine. For several years, control of gene activity by DNA methylation has been recognized as a logically attractive possibility, but experimental support has proved elusive. However, there is now reason to believe, from recent studies, that DNA methylation is a key element in the hierarchy of control mechanisms that govern vertebrate gene function and differentiation.
引用总数
学术搜索中的文章
KF Conklin, W Doerfler, RH Grafstron, M Groudine… - 2012
M Szyf, A Razin - DNA Methylation and Cancer Therapy, 2005