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To evaluate diagnostic performance of an enzyme-linked immunospot assay for interferon-γ (T SPOT-TB) in patients with suspected extrapulmonary tuberculosis (TB).

From January 2007 to December 2008, patients with suspected extrapulmonary TB were prospectively enrolled from 2 tertiary care hospitals.

A total of 138 patients with suspected extrapulmonary TB were enrolled; 50 patients had positive culture for Mycobacterium tuberculosis and 39 patients had probable TB. The sites of infection were lymph node (n=20), pleura (n=19), bone/joint (n=15), urinary tract (n=7), peritoneum (n=7), meninges (n=6), disseminated (n=5), intestine (n=3), pericardium (n=2), skin (n=2), throat (n=1), neck (n=1), and genitalia (n=1). The overall sensitivity and specificity were 79.8% (71/89) and 81.6% (40/49). The sensitivity ranged from 100% for tuberculous meningitis, tuberculous pericarditis, and …