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This Study was conducted to estimate the level of some antioxidant, including (Vitamin c, Glutathion (GSH), albumin, and Superoxide dismutase (SOD) activity). Also to determine Peroxynitrite radical (one of the reactive oxygen species ROS) and total protein in (88) infected women with Toxoplasmosis (Whose–anti–Toxoplasma gondii antibodies were Positive), in addition to (31) women,(whose anti-Toxoplasma gondii antibodies were negative as control group). The results showed that, serum vitaminC and glutathione levels were significantly lower (P< 0.05) in toxoplasmosis women than control group, however there was a significant increase (P< 0.05) in serum total protein and peroxynitrite radical in toxoplasmosis women, compared with control group. The study showed a significant reduction (P< 0.05) in albumin/globulin ratio in toxoplasmosis woman, while there were no changes in serum albumin and superoxide dismutase (SOD) activity in these infected women when compared with control group. This study concluded that, infection with Toxoplasma play a role in oxidative stress induction and reduced the antioxidant–defens systems.