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First, great thanks to almighty, the most merciful ALLAH, for enabling me to accomplish this work. I would like to express my thanks and full appreciation to my supervisor Assistant Professor Dr. Elham M. AL-Khashab who I will not forget her kindly helpfulness, guidance and support throughout the research. I highly appreciate her kindness and I always find an open door, a high scientific supervision and infinite patience in following up the research. My best honor to acknowledge the Dean of the College of Veterinary Medicine and Department of Physiology, Biochemistry and Pharmacology/College of Veterinary Medicine/University of Mosul/Nineveh-Iraq. Finally, I dedicate my thanks and gratitude to all white hands whose that help me in completed my research, and I would like to express my deepest gratitude to my supportive family and colleagues for guiding me in making this project a unique one.