作者
Yoshiki Kataoka, Hiroshi Okabe, Akihiko Yoshizawa, Sachiko Minamiguchi, Kenichi Yoshimura, Hironori Haga, Yoshiharu Sakai
发表日期
2013/1
期刊
Gastric Cancer
卷号
16
页码范围
84-93
出版商
Springer Japan
简介
Background
A recent randomized controlled trial (Trastuzumab for Gastric Cancer [ToGA] study) established standard scoring criteria of human epidermal growth factor receptor 2 (HER2) for gastric cancer and demonstrated the efficacy of trastuzumab for treating metastatic gastric cancer. The aim of the present study was to evaluate the frequency of HER2-positive cases by application of the standard criteria in patients with resectable gastric cancer and to examine the relationships between HER2 expression and prognosis, mucin phenotype, p53 status, and clinicopathological features.
Methods
A total of 213 patients were included in this retrospective study. All tumor samples were examined for HER2 expression by immunohistochemistry (IHC), HER2 amplification by in situ hybridization, and mucin and p53 expression by staining for CD10, MUC2 …
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Y Kataoka, H Okabe, A Yoshizawa, S Minamiguchi… - Gastric Cancer, 2013