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Dapagliflozin and Saxagliptin are very effectively used treatment for type II diabetes. They are very potent inhibitors of renal glucose reabsorption and dipeptidyl peptidase protein 4(DPP-4) and sodium glucose transport protein 2 and also they are called as DPP4 & SGLT2 inhibitors. They are generally administered as tablets. Determination of Dapagliflozin and Saxagliptin in pharmaceutical dosage form and bulk form, several analytical methods including UV, HPLC, LC-MS and HPTLC techniques has been developed. Methods indicating human plasma stability and impurity profiling are also described for both drugs. For qualitative and quantitative estimation of Dapagliflozin and Saxagliptin, these analytical methods can be used and it can also be used for its related degradants in bulk formulations and biological fluids. The following study depicts the review on analytical methods which includes estimating the …