作者
Bakhtawar K Mahmoodi, Kunihiro Matsushita, Mark Woodward, Peter J Blankestijn, Massimo Cirillo, Takayoshi Ohkubo, Peter Rossing, Mark J Sarnak, Bénédicte Stengel, Kazumasa Yamagishi, Kentaro Yamashita, Luxia Zhang, Josef Coresh, Paul E De Jong, Brad C Astor
发表日期
2012/11/10
来源
The Lancet
卷号
380
期号
9854
页码范围
1649-1661
出版商
Elsevier
简介
Background
Hypertension is the most prevalent comorbidity in individuals with chronic kidney disease. However, whether the association of the kidney disease measures, estimated glomerular filtration rate (eGFR) and albuminuria, with mortality or end-stage renal disease (ESRD) differs by hypertensive status is unknown.
Methods
We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and ESRD associated with eGFR and albuminuria in individuals with and without hypertension.
Findings
We analysed data for 45 cohorts (25 general population, seven high-risk, and 13 chronic kidney disease) with 1 127 656 participants, 364 344 of whom had hypertension. Low eGFR and high albuminuria …
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BK Mahmoodi, K Matsushita, M Woodward… - The Lancet, 2012