作者
Yao Liu, Sina Davari-Farid, Pradeep Arora, Jahan Porhomayon, Nader D Nader
发表日期
2014/6/1
来源
Journal of cardiothoracic and vascular anesthesia
卷号
28
期号
3
页码范围
557-563
出版商
WB Saunders
简介
Objective
To investigate the impact of early versus late renal replacement therapy (RRT) on mortality in patients with acute kidney injury (AKI) after cardiac surgery.
Design
Meta-analysis of 9 retrospective cohort studies and 2 randomized clinical trials extracted from the Medline engine from 1950 to 2013.
Setting
University medical school.
Participants
841 Patients.
Interventions
None.
Measurements and Main Results
A total of 841 patients were studied. Pooled estimates of the odds ratio with 95% confidence interval using a random-effect model were conducted as well as the heterogeneity, publication bias, and sensitivity analysis. Primary outcome was 28-day mortality, and secondary outcome was the intensive care unit (ICU) length of stay. The 28-days mortality rate was lower in the early RRT group (OR = 0.29, 95% CI, 0.16-0.52, p<0.0001, NNT = 5). Heterogeneity was high (I2 = 56%), and publication bias was low …
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Y Liu, S Davari-Farid, P Arora, J Porhomayon… - Journal of cardiothoracic and vascular anesthesia, 2014