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Aspirin reduces risk of colorectal neoplasia in randomized trials and inhibits tumor growth and metastases in animal models. However, the influence of aspirin on survival after diagnosis of colorectal cancer is unknown.

To examine the association between aspirin use after colorectal cancer diagnosis on colorectal cancer−specific and overall survival.

Prospective cohort study of 1279 men and women diagnosed with stage I, II, or III colorectal cancer. Participants were enrolled in 2 nationwide health professional cohorts in 1980 and 1986 prior to diagnosis and followed up through June 1, 2008.

Colorectal cancer−specific and overall mortality.

After a median follow-up of 11.8 years, there were 193 total deaths (35%) and 81 colorectal cancer−specific deaths (15%) among 549 participants who regularly used aspirin after colorectal cancer …