作者
Jana Kupusovic, Lukas Kessler, Sandra Kazek, Michal Kamil Chodyla, Lale Umutlu, Fadi Zarrad, Michael Nader, Wolfgang P Fendler, Zohreh Varasteh, Ken Hermann, Dobromir Dobrev, Reza Wakili, Tienush Rassaf, Johannes Siebermair, Christoph Rischpler
发表日期
2024/2/1
期刊
IJC Heart & Vasculature
卷号
50
页码范围
101340
出版商
Elsevier
简介
Purpose of the Report
Combined cardiac 68Ga-Fibroblast-Activation Protein-alpha inhibitor (FAPI) positron-emission tomography (PET) and cardiac magnetic resonance imaging (MRI) constitute a novel diagnostic tool in patients for the assessment of myocardial damage after an acute myocardial infarction (AMI). Purpose of this pilot study was to evaluate simultaneous Ga-68-FAPI-46-PET/MR imaging in the delayed phase after AMI.
Material and Methods
Eleven patients underwent hybrid 68Ga-FAPI-46 PET/MRI post AMI. Standardized uptake values and fibroblast activation volume (FAV) were calculated and correlated with serum biomarkers and MRI parameters.
Results
Significant 68Ga-FAPI-46 uptake could be demonstrated in 11 (100 %) patients after a mean period of 30.9 ± 22.0 days. FAV significantly exceeded the infarction size in MRI and showed a good correlation to MRI parameters as well as to serum …
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J Kupusovic, L Kessler, S Kazek, MK Chodyla… - IJC Heart & Vasculature, 2024