作者
Stuart Macgregor, Penelope A Lind, Kathleen K Bucholz, Narelle K Hansell, Pamela AF Madden, Melinda M Richter, Grant W Montgomery, Nicholas G Martin, Andrew C Heath, John B Whitfield
发表日期
2009/2/1
期刊
Human molecular genetics
卷号
18
期号
3
页码范围
580-593
出版商
Oxford University Press
简介
Alcohol dependence (AD) is a complex disorder with environmental and genetic origins. The role of two genetic variants in ALDH2 and ADH1B in AD risk has been extensively investigated. This study tested for associations between nine polymorphisms in ALDH2 and 41 in the seven ADH genes, and alcohol-related flushing, alcohol use and dependence symptom scores in 4597 Australian twins. The vast majority (4296) had consumed alcohol in the previous year, with 547 meeting DSM-IIIR criteria for AD. There were study-wide significant associations ( P < 2.3 × 10 −4 ) between ADH1B-Arg48His (rs1229984) and flushing and consumption, but only nominally significant associations ( P < 0.01) with dependence. Individuals carrying the rs1229984 G-allele ( 48Arg ) reported a …
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S Macgregor, PA Lind, KK Bucholz, NK Hansell… - Human molecular genetics, 2009