作者
Xiang-Zhen Kong, Samuel R Mathias, Tulio Guadalupe, ENIGMA Laterality Working Group, David C Glahn, Barbara Franke, Fabrice Crivello, Nathalie Tzourio-Mazoyer, Simon E Fisher, Paul M Thompson, Clyde Francks, ENIGMA Laterality Working Group, Karolinska Schizophrenia Project (KaSP), Karolinska Schizophrenia Project (KaSP) consortium
发表日期
2018/5/29
期刊
Proceedings of the National Academy of Sciences
卷号
115
期号
22
页码范围
E5154-E5163
出版商
National Academy of Sciences
简介
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language …
学术搜索中的文章
XZ Kong, SR Mathias, T Guadalupe… - Proceedings of the National Academy of Sciences, 2018