作者
Marleen HM De Moor, Stéphanie M Van Den Berg, Karin JH Verweij, Robert F Krueger, Michelle Luciano, Alejandro Arias Vasquez, Lindsay K Matteson, Jaime Derringer, Tõnu Esko, Najaf Amin, Scott D Gordon, Narelle K Hansell, Amy B Hart, Ilkka Seppälä, Jennifer E Huffman, Bettina Konte, Jari Lahti, Minyoung Lee, Mike Miller, Teresa Nutile, Toshiko Tanaka, Alexander Teumer, Alexander Viktorin, Juho Wedenoja, Goncalo R Abecasis, Daniel E Adkins, Arpana Agrawal, Jüri Allik, Katja Appel, Timothy B Bigdeli, Fabio Busonero, Harry Campbell, Paul T Costa, George Davey Smith, Gail Davies, Harriet De Wit, Jun Ding, Barbara E Engelhardt, Johan G Eriksson, Iryna O Fedko, Luigi Ferrucci, Barbara Franke, Ina Giegling, Richard Grucza, Annette M Hartmann, Andrew C Heath, Kati Heinonen, Anjali K Henders, Georg Homuth, Jouke-Jan Hottenga, William G Iacono, Joost Janzing, Markus Jokela, Robert Karlsson, John P Kemp, Matthew G Kirkpatrick, Antti Latvala, Terho Lehtimäki, David C Liewald, Pamela AF Madden, Chiara Magri, Patrik KE Magnusson, Jonathan Marten, Andrea Maschio, Sarah E Medland, Evelin Mihailov, Yuri Milaneschi, Grant W Montgomery, Matthias Nauck, Klaasjan G Ouwens, Aarno Palotie, Erik Pettersson, Ozren Polasek, Yong Qian, Laura Pulkki-Råback, Olli T Raitakari, Anu Realo, Richard J Rose, Daniela Ruggiero, Carsten O Schmidt, Wendy S Slutske, Rossella Sorice, John M Starr, Beate St Pourcain, Angelina R Sutin, Nicholas J Timpson, Holly Trochet, Sita Vermeulen, Eero Vuoksimaa, Elisabeth Widen, Jasper Wouda, Margaret J Wright, Lina Zgaga, David Porteous, Alessandra Minelli, Abraham A Palmer, Dan Rujescu, Marina Ciullo, Caroline Hayward, Igor Rudan, Andres Metspalu, Jaakko Kaprio, Ian J Deary, Katri Räikkönen, James F Wilson, Liisa Keltikangas-Järvinen, Laura J Bierut, John M Hettema, Hans J Grabe, Cornelia M Van Duijn, David M Evans, David Schlessinger, Nancy L Pedersen, Antonio Terracciano, Matt McGue, Brenda WJH Penninx, Nicholas G Martin, Dorret I Boomsma, Genetics of Personality Consortium
发表日期
2015/7/1
期刊
JAMA psychiatry
卷号
72
期号
7
页码范围
642-650
出版商
American Medical Association
简介
Importance
Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically overlaps with major depressive disorder (MDD) and is therefore an important phenotype for psychiatric genetics. The Genetics of Personality Consortium has created a resource for genome-wide association analyses of personality traits in more than 63 000 participants (including MDD cases).
Objectives
To identify genetic variants associated with neuroticism by performing a meta-analysis of genome-wide association results based on 1000 Genomes imputation; to evaluate whether common genetic variants as assessed by single-nucleotide polymorphisms (SNPs) explain variation in neuroticism by estimating SNP-based heritability; and to examine whether SNPs that predict neuroticism also predict MDD.
Design, Setting, and Participants
Genome-wide association meta-analysis of 30 cohorts with genome-wide genotype …
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MHM De Moor, SM Van Den Berg, KJH Verweij… - JAMA psychiatry, 2015