作者
Jorn Brouwer, Vincent J Nijenhuis, Ronak Delewi, Renicus S Hermanides, Wouter Holvoet, Christophe LF Dubois, Peter Frambach, Bernard De Bruyne, Gert K van Houwelingen, Jan AS Van der Heyden, Petr Toušek, Frank van der Kley, Ian Buysschaert, Carl E Schotborgh, Bert Ferdinande, Pim van der Harst, John Roosen, Joyce Peper, Frederick WF Thielen, Leo Veenstra, Dean RPP Chan Pin Yin, Martin J Swaans, Benno JWM Rensing, Arnoud WJ van’t Hof, Leo Timmers, Johannes C Kelder, Pieter R Stella, Jan Baan, Jurriën M Ten Berg
发表日期
2020/10/8
期刊
New England journal of medicine
卷号
383
期号
15
页码范围
1447-1457
出版商
Massachusetts Medical Society
简介
Background
The effect of single as compared with dual antiplatelet treatment on bleeding and thromboembolic events after transcatheter aortic-valve implantation (TAVI) in patients who do not have an indication for long-term anticoagulation has not been well studied.
Methods
In a randomized, controlled trial, we assigned a subgroup of patients who were undergoing TAVI and did not have an indication for long-term anticoagulation, in a 1:1 ratio, to receive aspirin alone or aspirin plus clopidogrel for 3 months. The two primary outcomes were all bleeding (including minor, major, and life-threatening or disabling bleeding) and non–procedure-related bleeding over a period of 12 months. Most bleeding at the TAVI puncture site was counted as non–procedure-related. The two secondary outcomes were a composite of death from cardiovascular causes, non–procedure-related bleeding, stroke, or myocardial infarction …
学术搜索中的文章
J Brouwer, VJ Nijenhuis, R Delewi, RS Hermanides… - New England journal of medicine, 2020