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This editorial is part of a series describing changes in the guidelines for authors making submissions to the British Journal of Pharmacology (BJP)(McGrath and Curtis, 2015); McGrath and Lilley, 2015; McGrath et al., 2015a, b). It sets out revised guidance for experimental design and analysis in preclinical pharmacological research for papers submitted to BJP. The main aim is to assist authors to provide the essential information that is required for their work to be reproducible and considered reliable.

We explain how authors are requested to follow this guidance, noting the advice applies to all work submitted after 1 August 2015. In the interests of flexibility, authors may argue for exemptions from the design requirements (Group sizes, power analysis, replicates and independent values; Randomization; Blinding) by including valid scientific justifications for doing so in the Methods section (explained below). The …