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Schizophrenia has been linked with childhood psychological abnormalities since it was first described, but studies of associations have not used population samples and so may be subject to bias. We have studied associations between adult-onset schizophrenia and childhood sociodemographic, neurodevelopmental, cognitive, and behavioural factors within a cohort of 5362 people born in the week March 3-9, 1946. Childhood data were gathered prospectively and case ascertainment was independent of routine follow-up of this cohort.

30 cases of schizophrenia arose between ages 16 and 43 years (cumulative risk 0·63% [95% Cl 0·41-0·86%]). Milestones of motor development were reached later in cases than in controls, particularly walking (difference in means 1·2 months [0·1-2·3], p=0·005), and up to age 15, cases had more speech problems than had controls (odds ratio 2·8 [0·9-7·8], p=0·04). Low educational …