作者
Meghan A Gonsalves, Tara L White, Jennifer Barredo, Andrew M Fukuda, Hannah E Joyce, Ashley D Harris, Linda L Carpenter
发表日期
2022/1/1
来源
NeuroImage: Clinical
卷号
35
页码范围
103049
出版商
Elsevier
简介
Introduction
Repetitive Transcranial magnetic stimulation (rTMS) is an FDA approved treatment for major depressive disorder (MDD). However, neural mechanisms contributing to rTMS effects on depressive symptoms, cognition, and behavior are unclear. Proton magnetic resonance spectroscopy (MRS), a noninvasive neuroimaging technique measuring concentrations of biochemical compounds within the brain in vivo, may provide mechanistic insights.
Methods
This systematic review summarized published MRS findings from rTMS treatment trials to address potential neurometabolic mechanisms of its antidepressant action. Using PubMed, Google Scholar, Web of Science, and JSTOR, we identified twelve empirical studies that evaluated changes in MRS metabolites in a within-subjects, pre- vs. post-rTMS treatment design in patients with MDD.
Results
rTMS protocols ranged from four days to eight weeks duration …
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